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Abbreviations ADC: Corticomedullary difference ADC: Apparent diffusion coefficient ASL: Arterial spin labelling CKD: Chronic kidney disease DKD: Diabetic kidney disease DWI: Diffusion-weighted imaging DWI-MRI: Diffusion-weighted MRI FOV: Field of view GLP-1RA: Glucagon-like peptide-1 receptor agonist Hs-CRP: High-sensitivity C-reactive protein RAAS: Reninangiotensinaldosterone-system ROI: Region of interest SEMPA trial: Effect of Empagliflozin and Semaglutide on Cardio-Renal Target Organ Damage in Patients with Type 2 Diabetes A Randomized Trial SGLT-2I: Sodiumglucose cotransporter 2 inhibitor TE: Echo time TKV: Total kidney volume TLCO: 12-Layer concentric objects TR: Repetition time UACR: Urinary albumin/creatinine ratio References Alicic RZ, Rooney MT, Tuttle KR (2017) Diabetic kidney disease: challenges, progress, and possibilities

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8 While the exact mechanisms behind tirzepatides impact on weight loss are still being studied, the results indicate its potential as an effective treatment option

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