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The enzyme is carried in blood and is a potent antioxidant, as also are the catalytic end-products: moreover, it strongly inhibits mast cells (27)

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Further, because the functional cells of the pancreas (both exocrine acini and endocrine islets) are highly secretory, FGF21 plays a protective role by enhancing the response to ER stress via activation of the UPR (189, 259)