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Acetyl-l-carnitine is a first-in-class epigenetic regulator of genes involved in analgesic action such as the metabotropic glutamate 2 [mGlu2] receptor gene, neurotrophic factors, and antioxidant enzymes (e.g., superoxide dismutase) (Fig

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It receives raw materials and has to synthesise GSH from scratch, which is an energy-dependent process limited by cysteine availability and the rate-limiting enzyme gamma-glutamylcysteine synthetase

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