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Here, too, researchers found no consistent increased risk from taking GLP-1 drugs in a 2025 analysis of data from 62 studies

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Because it takes multiple half-lives for a medication to fully clear, tirzepatide can remain in the body for several weeks after the final injection

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The study did, however, also highlighted several negative side effects, including constipation (118 occurrences), diarrhea (100 events), and abdominal pain (41 events per 1,000) ( Abdominal pain, nausea, vomiting, and diarrhea are among the gastrointestinal adverse effects linked to GLP-1 RAs