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89 Importantly, restoration of hypothalamic autophagy via nutritional interventions such as docosahexaenoic acid-acylated astaxanthin monoester (AST-DHA) supplementation or genetic activation of Atg5 ameliorates obesity and improves glucose metabolism in experimental models, 90 demonstrating that hypothalamic autophagy is not merely correlative but mechanistically regulatory

The numbers of people enrolled is normally larger than Phase 1 and participants may not be healthy adult volunteers if the ultimate target population is a specific social group such as children or the elderly

The Journal of clinical investigation 83 , 12471252, doi: 10.1172/JCI114008 (1989)