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Any temperature excursion above 8C causes irreversible protein denaturation even if the solution appears clear

In human studies, the evidence is mixed

In the US, a single months supply without insurance costs $900$1,300, more than the median monthly rent in dozens of states

These are the list prices, sometimes called Wholesale Acquisition Cost or WAC, that you would pay at a pharmacy counter with no insurance and no discount card

A November 2025 KFF Health Tracking Poll found that roughly 1 in 8 U.S

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