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This bioavailability gap means oral dosing requires higher amounts to achieve equivalent systemic exposure
Long-term human safety data does not yet exist
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Two common adjustments include stepping down, where the dose is gradually lowered while monitoring for cravings, or stretching out, which involves extending the time between doses (e.g., moving from weekly to every 1014 days)
Malaria proteases mediate inside-out egress of gametocytes from red blood cells following parasite transmission to the mosquito
