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Diabetologia 54(2):300307 Perreault L (2022) Prediabetes

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Based on the current 2026 eligibility criteria for other injections, Retatrutide would likely be reserved for patients with a specific BMI and weight-related comorbidities who are supported by a specialist weight management service

45 The second step is an irreversible rate-limiting reaction catalyzed by branched-chain -keto acid dehydrogenase (BCKDH), which is phosphorylated and inactivated by the specific kinase BCKDH kinase (BCKDK) and dephosphorylated and activated by Protein phosphatase 1 K (PPM1K)

[PMID: 25147782] PubMed record related to this compound for laboratory literature review