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Epidemiology of chronic kidney disease: an update 2022

You also retain less glycogen because carbohydrate intake drops, and glycogen holds water at roughly a 3 to 1 ratio

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However, it is not clear what contributed specifically to this effect on inflammation, though increasing evidence suggests that IGF-1 signaling is critical for maintaining immune cell homeostasis 44 , but the prospects of sex differences in the requirement for IGF-1 signaling in these cells is not yet known and will require further study

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