Phase 2 Trial Results (NEJM 2023) The landmark Phase 2 trial enrolled 338 adults with obesity (BMI 30) or overweight with comorbidities (BMI 27) but without diabetes
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Some states participate in the HHS-Administered Federal External Review Process, so you may also be able to get advice via their website or by calling 888-866-6205
Research protocols typically use 500mcg to 2mg per administration depending on study design, with localized dermal studies using higher doses (750mcg1mg) and anti-inflammatory models using lower doses (200mcg500mcg)
Semaglutide represents the culmination of that effort
The conservative approach is to continue using the vial but be aware that effectiveness may be reduced
