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Future translational research should aim to define the carnitine-responsive phenotype using integrated approaches, including serum acylcarnitine profiling, quantitative MRI of muscle fat, and CPT1A genotyping to enable precise patient stratification
Garcia-Cao I, Song MS, Hobbs RM, Laurent G, Giorgi C, de Boer VC, et al
(44) reported that the half-maximal effective concentrations (EC50) of GIP with GIPR and of GLP-1 with GLP-1R are 20 pM and 28 pM, respectively, without exhibiting cross-reactivity
Severe kidney disease or dialysis
102,103 Albiglutide is a long-acting GLP-1RA injected subcutaneously once a week