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Bariatric Surgery Sleeve gastrectomy and gastric bypass remain the most effective for severe obesity
This is where most adults start regardless of goal
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Mechanistically, the detrimental effects of EVs derived from toxic lipid-treated hepatocytes were attributed to miRNAs, proteins and lipids transported by EVs, e.g., miR-128-3p, inflammasome components, and CXC motif ligand 10 (CXCL10) [103]
Common adverse effects are predominantly gastrointestinal and typically emerge during dose escalation: Nausea (affecting 2050% of users initially) Vomiting and diarrhoea Constipation Abdominal pain and bloating Reduced appetite (therapeutic effect but may be excessive) Fatigue and headache Injection site reactions (redness, swelling or itching) These effects usually diminish over several weeks as the body adjusts
