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Nevertheless, the pooled analysis of 16 trials suggested improvements in the summary measure of patients' global functioning (assessed with the Clinical Global Impressions [CGI-I] scale) after 12 and 24 weeks of (but not after 52 weeks) of ALCAR treatment (1-3 g/day) and in cognitive performance (assessed with the Mini-Mental State Examination [MMSE] scale) after 24 weeks (but not at 12 or 52 weeks) (104)

Increased cAMP levels act as a secondary messenger, signaling the cell to produce and release growth hormone

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High-dose vitamin E therapy in glutathione synthetase deficiency

doi:10.1002/jms.4996

doi:10.1007/s00213-024-06735-1