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It is because the cell faces several obstacles in achieving the two major goals of metal cofactor delivery, which are incorporation of the native cofactor and exclusion of non-native cofactors

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For instance, pharmacological inhibitors of complex I not only deplete CoQ 10 H 2 but also impair ATP production, which activates AMP-activated protein kinase (AMPK) 108

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Its effects on sirtuin activation and DNA repair are more directly relevant to those symptoms than MOTS-cs metabolic signaling pathway