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Patients with higher initial HbA1c levels or greater insulin resistance may experience more dramatic improvements in blood glucose control, though these changes may take longer to fully develop
Loomba R, Abdelmalek MF, Armstrong MJ, Jara M, Kjr MS, Krarup N et al
Tirzepatide trials produced even better results, with the SURMOUNT-1 trial showing 15-22.5 percent body weight reduction depending on dose
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This phase 3b trial evaluates mirikizumab combined with tirzepatide versus mirikizumab with a placebo in adult participants with moderately to severely active CD and comorbid obesity (111)
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