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These continuously generated electrophilic hydroperoxy-phospholipids are neutralized by a specific GSH-dependent peroxidase, glutathione peroxidase 4 (GPX4), which prevents them from damaging membranes and driving ferroptotic cell death (7, 8)

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Our observation that CSF abnormalities (pleocytosis, elevated protein) and co-infections were more pronounced in HIV-positive patients aligns with previous evidence indicating that HIV enhances CNS inflammatory responses and susceptibility to opportunistic pathogens [30, 31]

10.1038/s41372-022-01412-7 11

Nanotechnology-based drug delivery for central nervous system disorders

PMC Lee, E., Park, H.-Y., Kim, S.-W