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DeChiara TM, Robertson EJ, Efstratiadis A

Reducing equivalents from NADPH are transferred to the FAD redox site of TGR comprised by the isoalloxazine ring of the flavin and a pair of nearby cysteines (C154/C159)

The specificity of the response was determined by treatment with an IGF-1R specific inhibitor, Picropodophyllin (PPP) that showed reduced BCL2 levels in GNE knockdown cells indicative of apoptotic response (Fig