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The first study, conducted in male mice, found that exenatide treatment did not significantly alter morphine-conditioned place preference, intravenous self-administration of the short-acting synthetic opioid remifentanil, morphine-induced locomotor activity, or the somatic signs of morphine withdrawal

In older persons, walking discomfort, functional impairment, and lower satisfaction scores are linked to elevated inflammatory markers such as C-reactive protein (CRP)

Gastrointestinal side effects, particularly nausea, vomiting, and diarrhea, can lead to reduced fluid intake and increased losses

Mulvihill and Drucker, 2014)