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To determine the solution structural model of the p53 TAD2 -FOXO4-DRI complex using NMR spectroscopy, we recorded several sets of NMR experiments on two types of complexes: 13 C, 15 N-labelled p53 TAD2 -FOXO4-DRI and 13 C, 15 N-labelled FOXO4-LRI D -p53 TAD2 (see methods)
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This hormone naturally occurs after eating and signals satiety to the brain
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But Eli Lilly seems to be aware of that, given its added focus on people with severe obesity and weight-related health problems like knee osteoarthritis
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