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After a median follow-up time of 9.1 months, the use of the GLP-1 receptor agonist-SGLT-2 inhibitor combination was associated with a 57% lower risk of serious renal events (2.0 v 4.6 per 1000 person years
Dose and titration schedule: The most significant factor affecting side effect timing is the rate of dose escalation
Consistency over 8 to 12 weeks is typically more impactful than short-term high dosing
Patience during escalation is critical
It does not suppress appetite or slow gastric emptying
1 2 3 4 5 "Polycystic kidney disease: inheritance, pathophysiology, prognosis, and treatment"
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