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Also known as LY3437943, retatrutide is a triple agonist that targets GLP-1, GIP and glucagon receptors

doi: 10.1038/s41580-023-00648-1 24 GanB

Unlike semaglutide, which is a peptide [molecule] that has to be protected from stomach acid degradation, orforglipron is a small molecule that survives the GI tract without special formulation requirements, says John

Clinical trial data shows a safety profile consistent with injectable semaglutide

Insulin-like growth factor (IGF) binding protein-2, independently of IGF-1, induces GLUT-4 translocation and glucose uptake in 3T3-L1 adipocytes. Oxidative Medicine and Cellular Longevity 2017 (2017)

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