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In human monocytes/macrophages, the amino acid transporter SLC7A5 has been shown to participate in immunometabolic reprogramming and to influence the intensity of inflammatory responses, suggesting that differences in transporter expression may be one of the key factors underlying tissue specificity and interindividual heterogeneity ( In addition, one-carbon metabolism and redox homeostasis also constitute important regulatory layers of macrophage polarization

Unlike apelin or spexin, METRNLs receptor has not yet been definitively identified, placing it among ligands whose translational development is constrained by incomplete mechanistic understanding

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Dydyk AM, Hameed S