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Schoretsanitis and Gastaldon found that patients who are co-prescribed antidepressants and the GLP-1 agonist semaglutide may be at risk of developing suicidal ideation
Published research has characterized MT-1 as a potent and selective MC1R agonist, distinguishing it from broader melanocortin receptor agonists
GLP-1 agonists affect blood glucose through multiple mechanisms
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In the SUSTAIN program, acute kidney failure was only reported in SUSTAIN 6, where its occurrence was similar between semaglutide and placebo ( In contrast to the incidental cases of AKI, the CVOTs mainly demonstrate a beneficial effect on renal outcomes, likely because of effects on cardiovascular risk factors (117)
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