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Surgery is typically recommended for higher BMI levels or obesity-related conditions
More importantly, a large-scale 3b-phase randomized controlled trial (SURMOUNT-5), which compared semaglutide with tirzepatide in 751 obese adults without type 2 diabetes, explicitly reported that male patients had an average weight loss approximately 6 percentage points lower than female patients after 72 weeks of semaglutide treatment, further verifying that sex is an independent factor affecting semaglutides efficacy [80]
However, if your doctor has particularly advised you to take vitamin B12 at night, it is best to follow their instructions, said Dr Mule
Most GLP-1s* are taken by subcutaneous injection, including the two that are approved by the FDA to treat obesity: Wegovy and Saxenda
10.1186/s12967-024-04853-0 217
Hold for 5 to 10 seconds after the plunger is fully depressed before withdrawing the needle
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