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Fusco J et al (2017): GLP-1/Exendin-4 induces -cell proliferation via the epidermal growth factor receptor

Youve likely heard of Ozempic, a type 2 diabetes drug that skyrocketed in popularity for its off-label use for weight loss

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Tirzepatides glucagon-receptor occupancy stays under 0.3% even at 15 mg. So its liver-fat reduction, its lipid improvements, and its heart-rate rise do not run through a glucagon arm the way retatrutides do

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This is why so many women have reported unexpected pregnancies on GLP-1 medications not because the drug is a fertility treatment, but because it's restoring the metabolic conditions your body needs to ovulate consistently