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l-carnitine has been frequently recommended as a supplement to increase physical activity in obese individuals due to its role in fatty acid metabolism, immune disorders, and in maintaining the mitochondrial acetyl-CoA/CoA ratio

Stier H., Vos E., Kenley D

This finding suggests that EE might also trigger AR to regulate MyHC expression, possibly through crosstalk with the IGF-1 pathway or other undefined pathways 39,53,54

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The conversation is different now than it was before this data existed