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While RWE is inevitably limited by the possibility of residual confounding [16], we welcome the careful attention paid by the authors of EMPRISE to minimise possible sources of bias [16], such as the steps taken to address concerns relating to immortal time bias that have been raised with previous RWE studies [19,20,21], providing more confidence in its results

Cagrilintide is Novo Nordisk's long-acting amylin analog currently under investigation for chronic weight management

The maximum recommended dose in research settings is 15 mg once weekly

The benefits of triple agonism extended also to MASLD in a subgroup of 98 people, fat content normalised in approximately 90% of people receiving the highest retatrutide doses [82]

For more information, that's clevelandclinic.org/firststep

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