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Jordan B, Margulies A, Cardoso F, Cavaletti G, Haugnes HS, Jahn P,

Glutathione is the bodys most powerful antioxidant essential for detoxification, immune defense, and cellular repair

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Slater S

760 These results together suggest that ACSL4 and LOX-catalyzed lipid peroxidation is involved in cerebral I/R injury, and inhibition of ACSL4 and LOX activity may be therapeutic targets for cerebral I/R injury

However, under a chronic glucolipotoxic environment, persistent hyperglycemia disrupts mitochondrial and endoplasmic reticulum homeostasis to trigger extensive oxidative stress and advanced glycation end-product accumulation, which directly activates various intracellular signaling cascades to initiate RCD pathways (14) ( Table 1 )