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Researchers continue evaluating how simultaneous receptor activation differs from single- and dual-receptor agonists, particularly regarding receptor selectivity, intracellular signaling, and metabolic regulation

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*Correspondence: Daiji Kawanami, [email protected] This article was submitted to Renal Pharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Priority Review Designation: If granted, compresses the review to approximately 6 months, potentially delivering approval as early as Q3 2027 rather than Q1Q2 2028