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In pancreatic cells, GLP-1R activation signals primarily through G proteinmediated signaling pathways involving cyclic adenosine monophosphate (cAMP), protein kinase A ( PKA ), and cAMP response elementbinding protein ( CREB ), thereby enhancing glucose-dependent insulin secretion and supporting -cell function

Since then, this receptor has been found in all tissues of the male reproductive system

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J., de Galan, B

Other reported effects including changes in libido and appetite, since alpha-MSH pathways touch multiple systems