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Researchsupported contexts Cystic Fibrosis Chronic otitis media with effusion HIVpositive individuals Idiopathic Pulmonary Fibrosis Chronic rhinitis Chronic smoking* and emphysema* *Both have been linked with lower glutathione levels in the epithelial lining fluid

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The exposed, charged surfaces of these crystals are thought to promote interactions with phospholipid membranes and serum factors, thereby contributing to the inflammatory response mediated by these crystals