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These findings emphasize the importance of GIPR activity and its anti-sclerotic role [32,33,34]

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Advances in Experimental Medicine and Biology , 1328

doi: 10.7759/cureus.17887 138 SongYWangHHuangHZhuZ

To evaluate the effect of naltrexone-bupropion on body weight, an age- and sex-matched control group consisting of patients with obesity who were indicated for pharmacotherapy but only on self-directed lifestyle management in the same Obesity Clinic of Queen Mary Hospital were identified during the same inclusion period

The cardiovascular benefits of GLP-1-RAs arise primarily through indirect systemic mechanisms, with limited evidence supporting direct effects on cardiomyocytes ( Figure 1 )