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For severe symptoms, short-term aids like PPIs, antiemetics, laxatives, or antidiarrheals bridge tolerance

Build stacks gradually over successive cycles

H1-histamine receptor affinity predicts weight gain with antidepressants

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5 KEY APPROACHES TO OVERCOME CHALLENGES IN PEPTIDE DELIVERY Protein engineering to resist enzymatic degradation Enzyme inhibitors and stabilizers for protection and stability PEGylation and albumin binding for half-life extension Enteric coatings for pH protection Encapsulation systems (eg, nanoparticles, liposomes) Permeation enhancers like SNAC Mucoadhesive systems for prolonged mucosal contact Several of these approaches are achieved by use of appropriate excipients