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However, mAb treatment tended to oppose age-related changes in 30 of these metabolites (22 marginally significant after FDR correction), including a reduction in the age-related rise of many glycerophospholipids, and a distinct clustering of metabolites from heart tissue in Old Con versus Old mAb-treated animals by PCA (Supplementary Fig

They work by stimulating insulin release, reducing glucagon secretion, and slowing digestion, which helps maintain stable blood sugar levels

In accordance to that, DPP4 expression levels of NAFLD patients were negatively correlated with HOMA-IR and BMI, and positively correlated with total cholesterol levels, but not with ALT, lactate dehydrogenase (LDH), or triglyceride levels

Naunyn Schmiedebergs Arch Pharmacol (2009) 379:3858

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