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These reductions are generally considered moderate sufficient to contribute meaningfully to glycaemic targets, but less potent than agents such as GLP-1 receptor agonists or SGLT-2 inhibitors in head-to-head comparisons

For the kidney, degeneration of glomerular structure and dilatation of Bowmans space, degeneration of proximal and distal tubule, vascular congestion and inflammatory cell infiltration were taken into consideration

Indeed, GLP-1 secretion is abolished upon corn oil infusion to the proximal duodenal compartment in vagotomized rats (Rocca and Brubaker, 1999)