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Kraus, D., et al

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NDA filed with FDA

Pharmacokinetic parameters were evaluated using the WinNonlin software (version 5.3) according to a non-atrioventricular model

For assessment of glucose-induced insulin secretion, glucose was given orally at a dose of 4 g kg 1 in 6 h fasted mice, followed by blood sampling at timepoints 0, 2, 5, 15 and 30 min after glucose administration