Our data show auto-AcT activity is used by SnCE1 to regulate important protein functions, i.e., affecting autoproteolytic processing needed for efficient cytosolic and mitochondrial distribution in the host cell and to stabilize the SnCE1 monomer, thereby improving its deSUMOylase activity as structurally tetramer formation and SUMO binding at the S1 site are mutually exclusive
Athauda D, Maclagan K, Budnik N, Zampedri L, Hibbert S, Aviles-Olmos I, Chowdhury K, Skene SS, Limousin P, Foltynie T
BMC Endocrine Disorders, 23 (245)
Scientific American (24 November 2014)
Karras added, Some products are suspensions so having recirculation technology integrated into the line is important
The next legally meaningful development will be a documented FDA decision or policy action