Advantage: Convenient, familiar, non-invasive Challenge: Peptides face proteolytic degradation in the stomach and small intestine Bioavailability: Estimated at approximately 38% based on comparative pharmacology (see below) Transdermal (Patch) Some researchers have explored transdermal patches to deliver peptides: Advantage: Avoids first-pass metabolism and GI degradation Challenge: Intact skin is a strong barrier to peptide penetration Feasibility: Not commonly available commercially
8(3):305313 Anisimov VN et al., Neuroendocrinology Letters , 2003
The long-term effects, optimal dosing, and potential drug interactions are not fully understood
Severe or prolonged B12 deficiency can lead to a range of neurological manifestations, including peripheral neuropathy, which may present as pain, paraesthesia (pins and needles), or altered sensation in the extremities
This selective permeability presents challenges in treating brain diseases, as medications that could benefit the brain cant always cross into it
Concurrently, she was prescribed a 3-month course of oral BPC-157 to address underlying gut inflammation
