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A considerable amount of research has defined the organization of the enteroendocrine system so that it is now recognized that there are basically three distinct subsets of these cells: pan-GI tract, stomach selective and intestine selective enteroendocrine cell types

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Any stomach disorders, or conditions like pernicious anemia where Intrinsic Factor is lacking, can prevent B12 absorption, as can intestinal inflammation such as Crohns disease if a damaged terminal ileum cannot take up vitamin B12

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