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To further confirm that the endogenous carnitine shuttle provides an acetyl-CoA pool that can be used for histone acetylation, we conducted 13 C 6 -glucose tracing in cells with knockdown of the carnitine acetyltransferases CrAT and CrOT

The study began at the beginning of the dark phase with a single dose of each agonist or vehicle, combined with an IP glucose tolerance test (IPGTT)

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Proper preparation and administration The timeline of retatrutide results assumes proper preparation and administration