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Because we found this transporter earlier and knew how to block the entry of glutathione, we already had the tools necessary to investigate its role in cancer metastasis, he says
The combination of low intracellular GSH levels and low expression of ABCC1 and ABCC2 in proliferative endothelial cells accounts for GSAO selectivity and subsequently for GSAO anti-angiogenic properties (Dilda et al., 2005a,b
In contrast to their beneficial effects, these enzymes also participate in formation of reactive intermediates of various compounds
However, highly sensitive preoperative and intraoperative diagnosis of tumor remains a challenge for the above imaging modalities, primarily due to their limited resolution, potential radiation exposure risks, and inability to offer timely feedback on treatment outcomes during surgery [7], [8]
WESTPHAL H et al
