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Preservation of Lean Muscle Mass By stabilizing blood glucose and optimizing insulin sensitivity, GLP-1 promotes the use of glucose and fat for energy efficiently, helping preserve muscle tissue while prioritizing fat loss

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Because many previous reports demonstrated that hypertension alone induces a shift from fatty acid oxidation toward increased glucose utilization in cardiac muscle, hypertension complicated with HFpEF might have additive effects on energy metabolic failure in heart

Think of it like suddenly changing the rules of a complex ecosystemsome species thrive, others struggle, and the whole community dynamic shifts

The direct regulation of GLP-1 on insulin expression is significant for type 2 diabetes (T2D) patients with simple glucose tolerance but normal insulin secretion ( 2 Peptide-based GLP-1 derivatives and small molecule compounds of GLP-1RA There are two main categories of GLP-1 receptor agonists, small molecule compounds and peptide-based GLP-1 derivatives as shown in Figure 1 , including exenatide, liraglutide, dulaglutide, etc