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S.BelvinM.KopczynskiC.ReichhartJ.-M.et al

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Excess weight accelerates cartilage breakdown through increased mechanical stress and contributes to a pro-inflammatory state that may further damage joint structures

Tirzepatide is generally studied as a dual GIP and GLP-1 receptor agonist, while Retatrutide is studied as a triple receptor agonist involving GIP, GLP-1, and glucagon receptor pathways

13 The peptide has also shown efficacy in healing fistulas 14 and promoting recovery in conditions like ulcerative colitis and multiple sclerosis

Metabolism, 57(5), 712-717