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Treatment initiation may be accompanied by closer clinical follow-up, lifestyle advice and increased patient engagement, which may influence suicide risk independent of GLP-1 RA effects

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Greater combined reductions in Hba1C 1.0% and weight 50.% with semaglutide versus comparators in type 2 diabetes

Overlaying the two conformers shows that the position of the R310 5.40 side chain guanidinium group in conformer 2 clashes with the agonist N-terminus in conformer 1 (Fig