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A randomized, double-blind, placebo-controlled study of histone deacetylase type 6 inhibition for the treatment of painful diabetic peripheral neuropathy
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In a phase 2, randomized, double-blind, placebo-controlled trial (NCT04881760) involving adults with obesity without type 2 diabetes, retatrutide (1 mg12 mg weekly) produced dose-dependent weight loss of up to 24.2% from baseline at 48 weeks, compared with 2.1% with placebo
Furthermore, FSP1 can mediate the regeneration cycle of CoQ10 relying on NADPH, thereby forming a functional synergy with the GPx4-glutathione antioxidant system (102)
