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People in the combination SGLT2i with oral semaglutide group had 1.92, 2.13, and 1.92 kg greater reductions in weight from baseline at 6, 12, and 18 months, respectively

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In experimental models, it may be included as a reference peptide when studying stress-response pathways, circadian-adjacent biology, and downstream molecular readouts linked to brainbody communication

Simpson, S