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By the way, it wasn't happening right away

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The Phase 3 OPTIONS study (536 subjects, 24 weeks) failed to show statistically significant weight loss compared to placebo

Study has demonstrated that GSDMD mediates the shift of tubular cells from apoptosis to pyroptosis in TLR4-regulated diabetic tubular damage, suggesting that GSDMD activation promotes the conversion from non-inflammatory apoptosis to inflammatory pyroptosis (227)

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