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MAMs are essential for the regulation of the neuronal Ca 2+ concentration via the SERCA, the ER channels inositol 1,4,5-trisphosphate receptors, the glucose-regulated protein 75, the MCU, and the voltage-dependent anion channel (VDAC) [61]

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Moreover, the recovery of adiponectin secretion observed in Retatrutide-treated mice is mechanistically relevant

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Dietary modification remains fundamental to MASLD treatment