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Pyridoxine at high or prolonged doses can cause sensory neuropathy

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La inhibicin de la NNMT se ha asociado con una mayor disponibilidad de nicotinamida adenina dinucletido (NAD), un cofactor esencial en el metabolismo celular, lo que puede influir en la actividad mitocondrial y favorecer los procesos de sealizacin dependientes del NAD, incluida la activacin de la sirtuina-1 (SIRT1)