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In general, the mitochondrial reduced:oxidised ratio is greater than that of the cytosol, resulting in a more reducing environment in the mitochondria (reflecting the high degree to which reactive oxygen species are produced within mitochondria)

In this article, we asked Dr Zoe Williams, an NHS GP specialising in lifestyle medicine, to explain the science behind why staying active is one of the smartest things you can do on a GLP-1 and how even small, consistent habits can make a big difference in how you feel and function over time

GLP-1 (glucagon-like peptide-1) is a hormone released from specialized cells (L-cells) primarily in the gut in response to eating

Standard therapeutic dose Ideal For Individuals seeking gut health support, managing IBD, IBS, or intestinal permeability, or looking for oral anti-inflammatory support without injections

For example, in cells harboring mutations in the mitochondrial TCA enzymes fumarate hydratase (FH) or succinate dehydrogenase, there is a massive spatial accumulation of fumarate and succinate within the mitochondria, which subsequently spill over into the cytosol and nucleus

The peptides for fat loss overview provides additional context for how these compounds fit into a comprehensive body composition strategy